Derry S, Wiffen PJ, Moore RA. (2017). Aspirin for acute treatment of episodic tension-type headache in adults. Cochrane Database Syst Rev1:CD011888.
Tension-type headache (TTH) is the most common form of headache in the world. Despite the benign nature, TTH has an enormous economic and social burden on society (consultation, work absence).
Is oral aspirin safe and effective in adults who suffer from frequent TTH episodes (2 to 14 per month) with moderate to severe intensity?
The predefined efficacy outcome of this meta-analysis, as defined by the International Headache Society preferred outcome of being pain-free at two hours, could not be calculated due to lack of data.Use of rescue medication was lower with aspirin than with placebo (low quality of evidence).Aspirin produced more satisfied participants than did placebo (very low quality of evidence).Considering the adverse events, no difference was present between aspirin and placebo (low level of evidence).
Results of this meta-analysis are valid in adults who suffer frequent episodic TTH with moderate to severe intensity. The appropriate dose of aspirin (500, 600 or 1000 mg) could not be determined due to the small number of the studies. Regarding adverse events, tolerability was evaluated for the single dose.
Hospices civils de Lyon, CHU Lyon-Sud
Centre Hospitalier Régional Universitaire de Brest
Marmara University School of Medicine