Cochrane Jan-June 18

The analgesic effect of nonsteroidal anti-inflammatory drug (NSAIDs) in chronic low back pain is minimal

SOURCE Wendy TM Enthoven et al. (2016) Non-steroidal anti-inflammatory drugs for chronic low back pain, Cochrane Database Syst Rev 2016 10;2:CD01208. CONTEXT Nonsteroidal anti-inflammatory drug (NSAIDs) are commonly used as a second-line therapy after paracetamol in chronic low back pain. CLINICAL QUESTION What is the analgesic effect of NSAIDs in common chronic low back pain? BOTTOM LINE Six studies showed a significantly ...

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Inefficacy of paracetamol in acute and chronic low back pain

SOURCE Bruno T Saragiotto, et al. (2016) Paracetamol for Low Back Pain. Cochrane Database Syst Rev 7;6:CD012230. CONTEXT Paracetamol is the first-line treatment for patients with low back pain and recommended in many guidelines. However, these recommendations are not based on the results of studies that include patients with low back pain. CLINICAL QUESTION What is the antalgic effect of paracetamol ...

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Beta-agonists and anticholinergics decrease the hospitalization rate for adults with severe asthma

SOURCE Kirkland SW, et al. (2017) Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma.Cochrane Database Sys Rev 11;1:CD001284. CONTEXT Between 7% and 22% of adults presenting to anemergency department for an acute asthma attack are hospitalized. The initial treatment most commonly used in the emergency management is nebulized beta agonists and short acting anticholinergic agents. However, ...

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Combined inhaled anticholinergic and beta-agonist use reduce hospital admissions of children with acute asthma

SOURCE Griffiths B, Ducharme FM. (2013) Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children.Cochrane Database Syst Rev21;8:CD000060. CONTEXT In an asthma attack, breathing difficulties occur as a result of airway narrowing secondary to inflammation, smooth muscle spasm and mucus secretion. Guidelines recommend the use of inhaled short-acting beta2-agonist (SABA) as the initial treatment for ...

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