Cochrane summaries: Jul-Dec 19

Potential interest of tranexamic acid for adult epistaxis control

SOURCE Joseph J, Martinez-Devesa P, Bellorini J, Burton MJ (2018). Tranexamic acid for patients with nasal haemorrhage (epistaxis). Cochrane Database Syst Rev 12: CD004328. CONTEXT Epistaxis is a common presentation to emergency departments.  Prevalence is highest in children and in the elderly, especially in the context of taking treatments disrupting haemostasis. The use of tranexamic acid (TXA), the efficacy of ...

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Oral Factor Xa inhibitors (xabans) better prevent thromboembolic complications than warfarin in atrial fibrillation

SOURCE Bruins Slot KMH, Berge E.  (2018) Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial fibrillation. Cochrane Database Syst Rev 3 :CD008980. CONTEXT The introduction of factor Xa inhibitors (FXaI), including xabans and parinux, offers an alternative to vitamin K antagonist (VKA) in the management of non-valvular atrial fibrillation (AF). Non-valvular AF is ...

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Don’t hesitate to prescribe direct oral anticoagulants in patient with atrial fibrillation associated with moderate chronic kidney disease

SOURCE Kimachi M, Furukawa TA, Kimachi K et al (2017) Direct oral anticoagulants versus warfarin for preventing stroke and systemic embolic events among atrial fibrillation patients with chronic kidney disease. Cochrane Database Sys Rev 11:CD011373. CONTEXT Atrial fibrillation (AF) is a common pathology and its management has changed recently with the introduction of direct oral anticoagulants (DOAC). Chronic kidney disease (CKD) ...

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Similar efficacy of short-term (≤ 7 days) versus prolonged use of corticosteroid therapy during an exacerbation of chronic obstructive pulmonary disease

SOURCE Walters JAE, Tan DJ, White CJ, Wood-Baker R (2018).Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 3:CD006897. CONTEXT Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the world. It is projected to rise to 4.5 million deaths in the year 2020. Ten percent of patients with ...

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Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease

SOURCE Vollenweider DJ, Frei A, Steurer, Stey CA, et al. (2018). Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Cochrane Database Systematic Rev 10: CD010257 CONTEXT Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by a progressive deterioration in respiratory function. COPD exacerbations (COPDE) are associated with increased morbidity and mortality, increased hospitalizations, decreased physical capacity, and ...

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